Monday, September 30, 2019

Death Penalty: the Christian View

In almost every society, there are crimes and violations of human rights. To deal with these things, there are laws that prescribe the prevention of their occurrences. However, if the law is broken, commensurate punishment is put on the violator. Depending on the seriousness of the crime, the punishment may be light such as imprisonment for up to one year with corresponding fines, or it could also be severe as death penalty. Capital punishment or death penalty is usually imposed on persons who committed heinous crimes and are those that endanger the safety of the society. Some countries and societies implement capital punishment while others do not. There are various reasons for this policy of countries, including the social view on the death penalty and the prevailing religious view in the society among others. One of the foremost arguments for the imposition of death penalty is that it acts as a deterrent for heinous crimes. Most societies throughout history have used capital punishment. Governments have also used this extensively to execute persons that do not conform to the laws and standards of conduct in the society. Throughout history, capital punishment was also used to suppress political dissent and to preserve the prevailing order in the society. Nowadays, the death penalty is being imposed on capital crimes such as treason against the state, espionage, and murder. In other countries, crimes that are of sexual nature such as rape, sodomy, and adultery are also punishable by death. Human trafficking, plunder and corruption, as well as drug trafficking are also punishable by death in other countries. The foremost reason being given for the imposition of capital punishment is its power to deter crimes. The argument says that if heinous crimes are punishable by death, would-be perpetrators of such crimes would protect their lives and they will not commit heinous crimes. On the part of the victims of such crimes, they also receive justice and redress for the injury through the capital punishment. On the other hand, capital punishment is a lot less expensive than life imprisonment (Paternoster, 1991). There are a lot of debates surrounding the imposition of capital punishment. Almost all countries in Europe, as well as in the Pacific area, and Latin America have abolished capital punishment in the name of respecting and protecting human rights. There are still a large number of countries that retained it, however. The United States Federal government with 36 States has retained it. Brazil imposes capital punishment only during wartime while countries in Asia and Africa also retained it. Notably, South Africa does not have capital punishment in spite of the high incidence of violent crimes such as murder and rape. South Korea no longer imposes capital punishment, as well as Uzbekistan, because it was not being used for a long time. A number of individuals, organizations, and human rights advocates object to the imposition of capital punishment. The questions they raise concern the effectiveness of capital punishment in deterring crimes. Moreover, there is always the possibility that the innocent person will be sentenced to death. Once the penalty is imposed, it can no longer be undone even if a separate investigation will render the accused as innocent from the crimes. There are also a number of instances in which minority groups are discriminated against in imposing capital punishment. Minority groups usually have lesser access to the best lawyers. As such, they run the greater risk of being proclaimed guilty for the crimes for which they are accused. With capital punishment, once death penalty is imposed, it is final. The person will have no chance to reform his ways or redeem his actions. He has been condemned by the courts to be forever separated from the rest of the society. In the 62nd General Assembly of the United Nations in 2007, the UN passed a resolution calling for the universal ban on capital punishment. This resolution asked the member-states of the UN to impose a moratorium on imposing the death penalty with the eventual plan of abolishing capital punishment. This resolution was made in recognition of the human rights of accused criminals and the possibility of redemption and change. Various religions also have varied responses to capital punishment. Even a particular denomination or religious group may not have a unified stand regarding capital punishment. Religious sentiments do play a significant part in the views of people regarding capital punishment. The Bible is replete with various passages that may seem to support or condemn capital punishment. The Old Testament, particularly, is based upon a morality of â€Å"teeth against teeth† and â€Å"life for life. † The books of laws of the Old Testament actually prescribe stoning to death the persons who commit serious crimes against God and against the community. A number of biblical scholars have considered the part of the Ten Commandments that say â€Å"You shall not kill† as a prohibition against individual cases of murder (The Ryrie Study Bible, Exodus 20:13). In the first place, the Christian faith believes that humans are created in the image of God. As such, a serious crime against another person is also a crime against God. In the Old Testament, premeditated murder was sufficient reason for the death penalty (Numbers 35:31, 33). Moreover, in Genesis 9:6, it can be read that â€Å"whoever sheds the blood of man, by man shall his blood be shed†. St. Thomas Aquinas also published his thoughts regarding capital punishment. He said that â€Å"the civil rulers execute, justly and sinlessly, pestiferous men in order to protect the peace of the state† (Summa Contra Gentiles, III, 146). Furthermore, St. Thomas Aquinas talked about the need to impose death penalty on the crime doers. â€Å"The fact that the evil, as long as they live, can be corrected from their errors does not prohibit the fact that they may be justly executed, for the danger which threatens from their way of life is greater and more certain than the good which may be expected from their improvement. They also have at that critical point of death the opportunity to be converted to God through repentance. And if they are so stubborn that even at the point of death their heart does not draw back from evil, it is possible to make a highly probable judgment that they would never come away from evil to the right use of their powers† (St. Thomas Aquinas, Summa Contra Gentiles, Book III, 146). The sacrifice of Jesus Christ on the cross is at the centerpiece of Christianity. Without such sacrifice, there would be no Christian faith. Such sacrifice is also a form of capital punishment in the sense that he bore the sins of the whole world. Such sin therefore requires the death penalty and Christ willingly went to the Cross to satisfy the requirements of a just and loving God for the remission of sins. Although the Old Testament has a number of provisions for death penalty, the New Testament appears to emphasize the love of God. This has been seized by anti-capital punishment advocates in moving towards the abolition of capital punishment. John 8:7 (NIV) of the Bible, which reads, â€Å"But Jesus bent down and started to write on the ground with his finger. When they kept on questioning him, he straightened up and said to them; â€Å"If any one of you is without sin, let him be the first to throw a stone at her. † is being taken as a passage supporting the abolition of capital punishment. In this regard, the sixth commandment is also being preached in a lot of churches as a prohibition against capital punishment. Several Christians also point to the love and grace of God as reason why capital punishment should not be instituted. Following this line of argument, it means that criminals are being given the maximum time for the possibility of repentance and redemption. With God’s grace and love, even criminals may still get a chance to reform their ways. Christian groups have diverse opinions and individual Christians do have the choice for their own preference and view apart from the official stand of their churches. Historically, the Roman Catholic Church accepted capital punishment based on the theology and views of St. Thomas Aquinas. The reason behind this is the way in which death penalty can deter and prevent crime. It is not a means for revenge. However, during the time of Pope John Paul II, the Roman Catholic Church revised this position. This position was defined by Pope John Paul II through the encyclical he released entitled Evangelium Vitae. As a result of this, the Roman Catholic Church now believes that capital punishment is not the best way to deal with crimes. Rather, capital punishment should be avoided except in cases where it is the only means available to defend the society from the criminal or offender. Given the present situation of penal systems, such need for execution is virtually non-existent. According to the Catechism of the Roman Catholic Church, â€Å"Assuming that the guilty party's identity and responsibility have been fully determined, the traditional teaching of the Church does not exclude recourse to the death penalty, if this is the only possible way of effectively defending human lives against the unjust aggressor. If, however, nonlethal means are sufficient to defend and protect people's safety from the aggressor, authority will limit itself to such means, as these are more in keeping with the concrete conditions of the common good and are more in conformity to the dignity of the human person. Today, in fact, as a consequence of the possibilities which the state has for effectively preventing crime, by rendering one who has committed an offense incapable of doing harm – without definitely taking away from him the possibility of redeeming himself – the cases in which the execution of the offender is an absolute necessity are very rare, if not practically nonexistent† (Catechism of the Catholic Church, no. 2267). Given this position, the Roman Catholic Church has affirmed the sanctity of life through this position. Such position aims to affirm the dignity and rights of a person even if he has committed some crimes. The position promoted and adopted by the Roman Catholic Church through Pope John Paul II is a revolutionary one and it is in keeping with the prevailing views in the world today regarding the abolition of death penalty. Depending on the stand of the churches, more liberal groups tend to be abolitionist, meaning they want to abolish death penalty. The more conservative denominations of Christianity tend to support the imposition of death penalty. Protestant Christian Churches also have their official stand regarding capital punishment. The Anglican and Episcopalian churches has opted a policy that condemns death penalty in 1988 through the Lambeth Conference of Anglican and Episcopal bishops. The United Methodist Church, as well as other Methodist churches all over the world has taken the position against capital punishment. The church says that it cannot support capital punishment on the basis of social vengeance and retribution. More importantly, capital punishment tends to be imposed more frequently to marginalized sectors of the society such as the uneducated, ethnic and racial minorities, the poor, and the disenfranchised. The General Conference of the United Methodist Church, which meets once in every four years, asked its bishops to oppose capital punishment and advocate for governments to impose a moratorium on the implementation of death penalty (United Methodist Church website, 2007). The Lutheran Church in America also opposes the death penalty. Such decision was made in 1991 through a social policy statement that the church released. The policy stated that vengeance is the main reason for the imposition of capital punishment. Furthermore, the Church believes that repentance, forgiveness, and redemption are necessary for true healing to be accomplished (ELCA, 2007). With this policy, the Lutheran Church joins the throng of Christian churches that support the abolition of death penalty. Given these stands of various churches, most denominations appear to support the abolitionist position. The interpretation of these churches of the Christian faith is one in which God’s love and mercy takes precedence over the imposition of punishment on the erring party. There are still churches within the Lutheran tradition that supports death penalty. They cite the stand of Martin Luther regarding death penalty and the way that this represents the justice of God. This also means that churches are now more and more in sync with the ideas and movements of other cause-oriented groups in the society. As time moves on, the views of Christian churches are also changing. There is almost a universal consensus regarding the importance of abolishing death penalty. For Christians, however, there are important issues at stake. This also concerns the emphasis on God’s justice, or God’s love. This also has an implication on the advocacies and ministries of Christian Churches. Traditionally, Christianity has emphasized the justice and the holiness of God and the way in which humans fall short of this. Moreover, justice means equality for all and that people get what they deserve. Given this framework of understanding, capital punishment is necessary. In recent years, however, there has been an emphasis on God’s love and grace. This means that the churches have redefined their role to dispense grace and promote forgiveness, healing, and reconciliation. This does not sit well, however, for the advocates of capital punishment. Because the major denominations such as the Roman Catholic Church, the United Methodist Church, and the Lutheran church have worldwide presence, this means that the abolitionist perspective has a better chance to be propagated all over the world. In this regard, the Christian church is working hand in hand with the United Nations, Amnesty International, and other human rights groups in promoting the dignity of humans. If the advocacy of rights groups and the churches succeed, this means that more and more countries might forego the capital punishment in the coming years. The effects of this on the incidence of crime and the social and governance policy of governments all over the world remain to be seen.

Sunday, September 29, 2019

Conquest of Panay and Other Islands Essay

Legaspi’s Cebu settlement had three important problems. First, there was a shortage of food and what the natives were used to eat was different from Spanish food. Second, misfortune struck the settlement. On November 1, 1565, a fire of unknown origin broke out in the settlement. Some twenty Spanish houses and the hut where masses were celebrated were burned. Third, the Spaniards were displeased with Legaspi’s order that no Spaniard should take anything from the Filipinos without paying for it. This, together with the shortage of food, led to a conspiracy on November 27 under the leadership of Pablo Hernandez. The captain of the San Pablo revealed the plot to the master-of-camp, Mateo de Saez. The latter immediately warned Legaspi, who lost no time in arresting the conspirators. Hernandez was beheaded–those were times of harsh justice–but the rest of the conspirators were pardoned. And fourth, Legaspi was also faced with the hostility of the Portuguese who did not enjoy Legaspi’s settling in Cebu. They sent ships to Cebu to spy on Legaspi’s activities. In 1568, and again the following year, a Portuguese captain, Gonzalo de Pereira, blockaded Cebu in order to starve the Spaniards. With the aid of the Cebuanos, however, Legaspi withstood the blockade and succeeded in forcing Pereira to lift the blockade and leave the Philippines. In the midst of all these problems, the first reinforcements from Mexico arrived in Cebu on board the galleon San Geronimo on October 15, 1566. This made Legaspi happy, for it brought not only the news that Urdaneta had safely arrived in Mexico but much-needed soldiers from Mexico as well. Later two more galleons from Mexico arrived in Cebu on August 20, 1567, bringing additional reinforcements and supplies. They were commanded by two young grandsons of Legaspi’s–Felipe de Salcedo, 20 years old, and Juan de Salcedo, 18. With these reinforcements, Legaspi sent out various explorations to the neighboring islands for the purpose of securing more food and establishing friendly relations with the datus of the other islands. Later Legaspi received the information that food was abundant in one of the islands in the north. In 1569 he directed his men to sail to Panay. There, on the banks of the Panay River, Legaspi founded the second Spanish settlement in the Philippines. As in Cebu, he won the friendship of the Panay inhabitants by his policy of attraction. Many of these inhabitants were converted to Christianity by Augustinian missionaries. After that, Legaspi never encountered the problem of food shortage, for the natives brought the needed provisions to him. Legaspi was now ready to spread the rule of Spain to the other islands in the archipelago. With Cebu and Panay as bases, he ordered his men to explore the other Visayan islands. Captain Luis Enriquez de Guzman explored and conquered Masbate, Burias, and Ticao and claimed these for the Spanish crown. He got as far as the Bicol region, then known as Ibalon. In January 1570 Legaspi sent his warlike grandson, Juan de Salcedo, on an expedition farther to the north. With forty Spanish soldiers and some 500 Visayans, Salcedo landed at Ilin Island, just south of Mindoro, and took it for the king of Spain. From Ilin he sailed to another island, Lubang, northwest of Mindoro and close to the mouth of Manila Bay. There he met stiff resistance from Muslim defenders. Salcedo subdued them and finally captured Mamburao. This brought the Spaniards almost to the entrance of Manila Bay. Salcedo then returned to Panay to report to his grandfather what he had done.

Saturday, September 28, 2019

Sexual Orientation and Inequality Term Paper Example | Topics and Well Written Essays - 3000 words

Sexual Orientation and Inequality - Term Paper Example This paper examines historical discourse on sexuality and gender identity how this history informs perceptions of sexual orientation and gender inequality. This paper traces the history and development of the conceptualization of gender roles and gender identity and how sexual orientation is dictated by those roles and identities. Therefore this paper is divided into two main parts. The first part of this paper examines the history and development of heterosexuality as a social construction of gender roles, gender identity and sexual orientation. The second part of this paper examines the history and development of non-heterosexual identity and how traditional gender roles and identity influence how non-heterosexual identities are treated by the dominant heterosexually constructed society. Sexual Orientation and Inequality Introduction Gender inequality on the basis of sexual orientation is deeply rooted in social constructs that dictate gender identity and gender roles (Tomsen & Mas on, 2001). Historically, sexuality was informed by a perception that heterosexuality is the norm and sexuality is understood by reference to heterosexual norms and standards (Kitzinger, 2006). In this regard, heterosexual norms typically link heterosexuality to nature and thus being heterosexual means being normal or being normal (Sullivan, 2003). Therefore homosexuality, lesbianism, and bisexuality are judged by reference to the dominant heterosexual norm. This paper examines the definitions and historical developments informing sexual orientation and gender identity and identifies why sexual orientation forms the basis for gender inequality. It is argued that although, non-heterosexuals have made significant gains in terms of political, legal and social acceptance, preconceived notions of non-heterosexuality continues to be a basis of social marginalization. It would therefore appear, that marginalization on the grounds of sexual orientation may never be fully eliminated. It would appear that as long as cultural institutions formally alienate non-heterosexuals, it can be expected that social alienation of non-heterosexuals will be perpetuated. This research paper is divided into two main parts. The first part of this paper examines the history and development of heterosexuality and what this means for conceptualizing non-heterosexual identities. The second part of this paper examines the history and development of the conceptualization non-heterosexuals and how this conceptualization has changed over time. Heterosexuality Up to the 1980s, heterosexuality was defined in dictionaries as natural sexual relations. It was only during the 1980s that dictionaries defined heterosexuality as sexual relations between persons of the â€Å"opposite sex† (Sullivan, 2003, p. 119). It therefore follows that historically heterosexuality was defined in a way that distinguishes non-heterosexuality as abnormal and thus formed the basis of discrimination on the grounds o f sexual orientation. Despite a revised dictionary definition of heterosexuality, attitudes toward heterosexuality as natural sexual relations remained unchanged for the most part. As Caplan (1987) observed, any indication that individuals did not conform to heterosexual norms was perceived as a threat to normative perceptions of sexuality and what should be normal. Although prejudice against non-heterosexuality has declined persistently since the 1990s, prejudice continues to remain prevalent throughout the US (Herek, 2000). In the US heterosexism and religious fundamentalism†

Friday, September 27, 2019

Desert Flower by Waris Dirie Essay Example | Topics and Well Written Essays - 3500 words

Desert Flower by Waris Dirie - Essay Example II. Plot Summary Waris Dirie was born into a nomadic tribe in Africa and deserts of Somalia were her playgrounds in childhood. Life there was a tough option but with no other alternatives she continued to live there, working and tending cows and she grew into a tough individual. She was a victim to the superstitious traditions of genital mutilation, but she had no knowledge about its true significance at that young age of 5. She was given to understand that it was an inevitable procedure to become a woman. Her mother was a party to that cruel exercise on her body and a professional killer woman knifed the outer portion of her genitals and then sewed it up. That was known as the procedure of circumcision, she survived it but some of her close ones, like sister Halemo and two other cousins had died. At the age of thirteen she ran away from the house to stall the efforts of her scheming father who wanted to give her in marriage to an aged individual. She reached Mogadishu to join her si ster Aman who had also escaped from the house. She stayed with her sister and aunt and then reached London with her uncle who was an Ambassador, as a maid to his family. She took education and soon came to realize her inner potentialities. She wanted to transcend from her status as a nomadic woman and achieve something tangible in life. She was in London for 4 years and when it was time for her uncle and family to return to Somalia, she insisted on staying back. She led a solitary life with none to support her. She got acquainted with Malcolm Fairchild, a photographer and then succeeded in getting some jobs in London. She married her friend Marylyn’s brother and got a passport. Opportunities fell to her lot to travel to different countries for modelling and soon she became a... Center of discussion in this paper is â€Å"Desert Flower†, the memoir of Waris Dirie. It is the story of how a nomadic girl from a backward country, Somalia, rises to become an internationally known super-model and then takes the top assignment as the UN Ambassador for the cause of women. She is a remarkable beauty with extraordinary courage. Her march from the village mud roads to the fashion runways of Milan, Paris and London reads like fiction. The name of the book is â€Å"Desert Flower†, but actually the author deserves that name. Cathleen Miller is the ghost writer of the book but the facts and the emotions of the content belong to Waris. The sum and substance of the book according to her own understanding is: Everything decided for her by God and she is just doing the work allotted to her by Him. Birth and death are in the hands of God and none has say on that issue. She will continue to take chances and she does the same throughout her life. During her run, she is nearly eaten by a lion, but the lion somehow spares her. About that encounter she writes, when I realized the lion was not going to kill me, I knew that God had something else planned, some reason to keep me alive. "What is it?" I asked as I struggled to my feet. "Direct me.† Some individuals are the victims of destiny; some are the creators of their destiny. Waris belongs to the latter category and with her fighting qualities, grit and determination she turned every situation to her advantage.

Thursday, September 26, 2019

In Freud's view what is the difference between the ego, id and Essay

In Freud's view what is the difference between the ego, id and superego, and how do they interact - Essay Example The Id Freud conceptualizes the id in terms of uncoordinated instincts, and as the unorganized part of the personality structure, the id only contains basic instinctual drives, and is present from the time individuals are born (McLeod). The id is the origin of human needs, wants, desires, and impulses, especially the sexual and aggressiveness-related drives, and it is governed by the pleasure principle, which is the psychic force that arouses the tendency to seek the immediate gratification of impulses as soon as they emerge. The id encompasses the libido, the primary source of the instinctual force, and it seeks to avoid pain or un-pleasure aroused by the rise in instinctual forces; in this respect, the id demands immediate satisfaction. When individuals satisfy their needs or drives, they experience pleasure; however, since the id does not care about reality or the needs of other people but its own satisfaction, it is not a stable personality. The fact that the id is present right from birth implies that it encompasses all the inherited traits, and the minds of babies being purely id-oriented, it implies that the id is important in babies since it contains the life instincts that are very important for pleasurable survival. For instance, when babies are hungry, they cry to be fed, and when they are wet, they also cry for their diapers to be changed; in this respect, the id enables the babies to seek immediate gratification. This explains why babies have no sense of wrong or right as the id knows no judgment of value, of what is wrong or right; in that respect, so long as there is a need it must be satisfied immediately. The Ego The ego, unlike the id, is the organized, realistic component of the psyche, which only acts according to the reality principle, and seeks to grant the id satisfaction in realistic ways that are beneficial in the long term rather than only in the short term. In this regard, Freud perceives the ego to be an individual’s conscienc e that makes them understand that their own desires may vary considerably from those of other people around them. In that sense, the ego will try to meet an individual’s needs but at the same time, it will consider the reality in the surrounding world since it understands that actions have consequences or effects, which may be positive or negative. The ego, therefore, plays a very fundamental function in individuals since it tries to balance thinking before carrying out decisions or before taking actions, to ensure that they bring benefits in the end rather than pain. The reality principle governing the ego is the regulating mechanism, which enables individuals to delay satisfying their immediate needs and drives until the appropriate time. For instance, the ego will enable individuals to wait patiently at a restaurant for their food, rather than grab food off other people’s plates; without the ego, individuals would be grabbing things from people as soon as they have felt a need that needs to be satisfied immediately. The Super Ego Unlike the id and the ego, the super ego plays a very fundamental moralizing role in the psyche since it aims for nothing short of perfection by incorporating ego’s ideals and punishing misbehavior with guilt feelings (Eugenes). According to Freud, the super-ego incorporates the learnt values and morals of society, which are gained from interactions within family and

Wednesday, September 25, 2019

Reading and writing Essay Example | Topics and Well Written Essays - 250 words - 1

Reading and writing - Essay Example d a huge a place in the society and as upsetting as it is, it is largely due to the fact that people are naturally attracted to such pieces of news that in turn causes the media to pander to the demands of the public. Even the most notable journalists resort to sensationalism in order to maximize profits and attract attention. (Mitchells, 2007) Sensational news directs unnecessary amount of scrutiny towards people, they can either be defamatory but certain people use such incidents to order to boost their own fame through notoriety. The case of O.J. Simpson epitomizes this aspect and another example of such an incident would be Bill Clinton’s alleged affair with a young white house intern Monica Lewinsky. Both of these cases remained in the limelight of media for a very long time and despite the fact that such pieces of news were largely scandals they were exaggerated beyond proportion and now such atrocious incidents have become highly infused in the popular culture of the American society. These are just a few notable examples but there are other cases as well that were subjected to intense Sensationalization. According to my personal beliefs, there is no way sensationalism can ever be justified because it contradicts the professional code of ethics that every journalist must abide by. The ethical code requires all journalists to refrain from making discriminatory references that might create discord amongst the society, factual reporting and adopting an objective or unbiased stance when it comes to the reportage of the news. However, despite the breaches of the aforementioned ethical code, sensationalism has become an important part of our society. (Mitchells,

Tuesday, September 24, 2019

Community and public health Assignment Example | Topics and Well Written Essays - 250 words

Community and public health - Assignment Example In addition, it aims at improving the value of healthcare, efficiency, quality while minimising spending, and making healthcare system more transparent and accountable to the diverse population, which are key elements in the Act (Mason et al., 2014). The American Academy of Nursing, in conjunction with several nursing organization, has overwhelmingly supported the efforts to reform the health care system. Nurses have steered the expansion to allow people to access cost-effective and high-quality services in the public sector with more emphasis on primary and preventive care services. The affordable care act shall make the nurses model both individual and health care system to be more beneficial to patients than before. Nursing as a profession shall actively get involved in the leading efforts to improve patient care and minimise cost, which as an integral part of the professionals values, knowledge and skills. Nurses shall enhance health promotion among the diverse population by educating the population about the best prevention, acquisition of health care and efficient ways of getting medical help in the evolving healthcare system (Boykin et al.,

Monday, September 23, 2019

Personal statement of character Essay Example | Topics and Well Written Essays - 500 words

Personal statement of character - Essay Example hat the maker of drugs should have the traits that are required to understand the philosophy behind the administration of drugs and their role in healing. When I first considered being a pharmacist, I did not base my decision on my mere aptitude at math and chemistry; it was also my personal qualities that motivated me to pursue a profession which is a crucial cog in the healing process. One of the most important qualities that can be of great assistance to me in my career as a pharmacist is my compassion for others. During my nursing profession, I often found myself empathizing sincerely with the patients and understanding their pain and suffering. My experience as a nurse has made me sensitive to the suffering of the people and the pain that they have to bear due to disturbances in their normal physiological functions. Bearing this in mind, my focus when preparing drugs would be solely to mitigate the pain and affliction of these people. I am a compassionate by nature and my poised and calm personality can be a great asset during my professional practice as a pharmacist. My experience as a nurse has equipped me with the skill of appeasing patients- an attribute that I feel is necessary for satisfying frightened and stressed customers. I am also good at sports and have remained an active sportsperson in tennis and basketball in my school and college years. Being a team member and working with the rest of the team members have equipped me with a very valuable trait- team work. The profession of pharmacy requires that the pharmacist interacts with a number of professionals from the health care field. These include doctors, drug retailers, lab technicians etc. Working in teams for the success of the team and assisting team members to improve their performance has not only made me more helpful but has also made me more goal-driven. My ambition has enabled me to deliver excellent results when working on my own. Table tennis is a sport that requires players to develop

Sunday, September 22, 2019

Cross-cultural communication Essay Example for Free

Cross-cultural communication Essay Cross-cultural communication is an art which cannot be practiced without verbal and non-verbal communication. Interacting with people of the same culture requires certain skills so interacting across different cultures is a task ahead. Every culture doesn’t only have its own language but also has a unique set of codes and customs; this makes verbal and non-verbal communication both important. With over 3000 languages and many dialects spoken in the world today, it is impossible for everybody to learn all of them. This humungous variety that is available creates problems for the cross-cultural communication. Apart from this the way words are uttered; the accents used add to the problem. In this case, the standard language makes cross-cultural communication easier. For instance one form of Arabic language is most common so it is widely used; Modern Standard Arabic. The same way an official language is given preference when interacting with people of different cultures. A country having many provinces synchronizes on a national language. Every province may have a different language but there is one language which is common to all. The same way the standard language for communicating across countries and continents is English. It is the most widely spoken language in the world and helps to overcome many ethnic differences. The reason that English is proved helpful in breaking barriers is that it is derived from other languages so many cultures can easily relate to it. Language is especially important when the interaction is not on face to face basis. In this type of interaction one cannot get the aid of body language and communication is solely dependent on words. Etiquettes over here emphasize the importance of verbal communication. People should take care of their words; they shouldn’t offend others while speaking. A word which means something good in one language might mean something totally appalling in the other. Care must be taken while selecting words for cross-cultural communication. Slang language especially should be avoided. While the importance of verbal communication is obvious and can be easily seen, the importance of non-verbal communication comes through experience and knowledge. The value of non-verbal communication is in fact greater than that of verbal communication across cultures. When the verbal communication is weak, non-verbal communication is relied upon. Gestures, eye contact, physical appearance, touch, expressions, silence and behavior speak a lot when we fall short of words. Majority of French people don’t understand English language and only communicate in their own language. When tourists visit their homeland it gets difficult for them to communicate. This is where non-verbal communication becomes very important. Actions help in communicating and letting people of different cultures interact without language. Some gestures are world widely same, others may show one thing in one culture and another in another culture. (Reisinger, 2009). Personal space or physical proximity is also an important non-verbal communication element. In some cultures, people dislike standing too close and maintain some distance between them while in others people stand pretty close while talking and consider it rude to stand apart. To make cross-cultural communication easier people are learning more languages but it is also very important to research other cultures and understand their non-verbal communication. Even if language skills are not appropriate, messages can be conveyed if body language is used correctly. It is said that non-verbal communication makes the first impression because even before a person opens the mouth to utter a word, an impression is made. (LeBaron, 2003). Non-verbal interaction is important during face-to-face communication. It can occur through the sensory channels- sight, sound, smell, touch or taste. Listeners process the non-verbal communication apart from the verbal one. Charles Darwin was the first man to conduct a study of non-verbal communication. His book â€Å"The Expressions of the Emotions of Man and Animals was published in 1872. In this writing he argued that animals show emotions on their faces so they communicate a lot without speaking (Davis, 1999). It is said that verbal communication is more important in public speaking and non-verbal communication is very important in interpersonal relationships. Also it is considered more polite is ideas are conveyed by non-verbal cues rather than verbal, especially in embarrassing situations. There are five primary functions of nonverbal bodily behavior in human communication: †¢ Express emotions †¢ Express interpersonal attitudes †¢ To accompany speech in managing the cues of interaction between speakers and listeners †¢ Self-presentation of one’s personality †¢ Rituals (greetings) Another important thing is that during non-verbal communication it is easier to catch someone who is not speaking the truth. Facial expressions and hand movements tell a lot. This also helps the interviewers when people go abroad in search of jobs. An interesting point of view of non-verbal communication is that it is rich in beauty. Cultural dance competitions are held and different cultures perform their own dances. Without speaking a whole story is formed and the message is conveyed. This is the beauty of non-verbal communication (Storti, 1994). It is important to address issues of both verbal and non-verbal communication. It is because in this competitive age those who have an edge over others and are good at everything are successful. References: Storti, C. , 1994, â€Å"Cross-Cultural Dialogues†, Available at http://www. kwintessential. co. uk/cross-cultural/book/crosscultural-dialogues. html [ Accessed May 12, 2010] Davis, L. ,1999, â€Å"Doing Culture: Cross-Cultural Communication in Action†, Available at http://www. kwintessential. co. uk/cross-cultural/book/communication-action. html[ Accessed May 12, 2010] LeBaron, M. ,2003, â€Å"Cross-Cultural Communication, Available at http://www. beyondintractability. org/essay/cross-cultural_communication/ [ Accessed May 12, 2010]

Saturday, September 21, 2019

Teens Decreasing Morality Essay Example for Free

Teens Decreasing Morality Essay Some aspects of moral values among university students in three societies: Poland, Australia and the Philippines J.J. Smolicz, D.M. Hudson and M.J. Secombe1 Graduate School of Education, Adelaide University The paper reports the findings from a comparative study of moral values undertaken among university students from five universities in the Philippines, Poland and Australia. The aim of the study was to compare the way students brought up in different cultural traditions, but subjected to the homogenizing trends of globalization, evaluated what they deemed as the most appropriate solutions to some of the basic life dilemmas facing individuals today. The respondents were senior undergraduate and postgraduate students drawn from education and social science faculties in two independent Catholic and three secular state universities. A total of 448 students participated in the study, with 80 to 100 students originating from each university. This paper presents a detailed analysis of one example from each of three categories of moral dilemmas, in which students were asked to state their position in relation to twelve issues including abortion, extramarital affairs and stealing. In addition to providing concrete data on themselves, students indicated whether they believed the actions listed were wrong, acceptable or dependent on circumstances. The students’ responses to the issues showed a generally consistent position for each university along a value orientation continuum ranging from Traditional Christian to ‘Post-modern Individualist’. The degree of support for Traditional Christian values varied, however, from issue to issue according to the university and country under investigation. moral values; abortion; infidelity; stealing; tertiary students; international. INTRODUCTION As a result of global secular influences, it could be expected that responses to moral dilemmas would have become more uniform across different cultural and ethnic and religious groups. In order to ascertain any possible modification to or rejection of traditional moral values crossculturally, the study sought the views of young people who were university students in three different countries and in institutions with different ideological profiles. The researchers had access to the collection of comparable data in Poland, the Philippines and Australia countries very different in their regions, cultures and histories. It should be stressed that the study did not aim to take the form of a statistical analysis of variables to test a pre-established hypothesis which could lead to any predictions for a wider population. This comparative study was not funded by any organisation, but was the result of co-operative efforts among colleagues in the three countries concerned. The authors, in particular, would like to express their gratitude to Ms Monika Koniecko, Professor Elzbieta Halas, Dr Illuminado Nical, Ms Susana Manzon and Mr Robert de la Serna for the contribution they have made to the data collection and analysis of this paper. The theoretical framework of the study is based on the humanistic sociological conceptualization of Znaniecki, in which the term ‘moral values’ refers to the meanings which group members are expected to accept as a guide to right and proper conduct and the way in which they should act in their daily life. Znaniecki (1963: 267-70) draws an important theoretical distinction between the ideological attitudes which individuals profess in terms of the religious and moral values of their group, and the tendencies to action which these same individuals reveal in the specific contexts of daily life. UNIVERSITY PROFILES Data were gathered from a total of 448 respondents, drawn from five different universities. The number in each institution ranged from 80 to 109 (80 in Leyte and Adelaide; 89 in Warsaw; 90 in UAP and 109 in KUL). In Poland, the student respondents were drawn from two universities. One of these can be regarded as firmly set within the Catholic tradition. In 1918 the Catholic Church established the Catholic University of Lublin (KUL) as a privately funded institution in a provincial centre in the east-central part of Poland. Over the period of Communist rule, it functioned as the bastion of Catholic religious and moral values in Poland. Today it is a medium-sized university with faculties reflecting its religious base: Theology, Canon and Civil Law, Christian Philosophy, Humanities, and Social Sciences as well as specialised institutes in Polish Church History, Higher Religious Education and Migration. Many of its students have gone to the priesthood and a variety of leadership positions in the Church and society at large. The second Polish university which provided respondents for this study was Warsaw. A state institution, originally founded in the early nineteenth century, Warsaw is a very large university, with a full range of humanities, social science and natural science faculties. Its position in the heart of a capital city, renowned for its high culture in music, art, literature and the theatre, yet traditionally strongly linked to the Polish Catholic Church, has had an important influence on its ethos in providing access to moral values based in the Catholic tradition, as well as its more atheistic, anti-clerical counter-tradition. Two other groups of respondents were drawn from universities in the Philippines. One set was provided by the University of Asia and the Pacific (UAP), which is a private university in Manila, established by the Opus Dei order of the Catholic Church. Its ethos reflects the Opus Dei dedication to Catholic spirituality and emphasis on intellectual, political. educational and business leadership. It is best known for its high profile research specialisations in economics, political economy and business management, as well as its undergraduate College of Arts and Sciences. Its fee-paying structure and high entrance standards make it an à ©lite institution, both socially and academically, and its total enrolment of around two thousand students is still relatively small. The second Philippines institution from which respondents were drawn was the provincial state university at Tacloban on the island of Leyte in the eastern Visayas. The Leyte Institute of Technology (LIT) sees its role as providing for the practical educational needs of the surrounding community which has maintained a strong commitment to Catholic values reflecting the local community. It offers degrees in vocational disciplines, applied science and technology and teacher education, with a particular emphasis on post-graduate studies in education. At present time there are around seven thousand students enrolled at the Leyte Institute. The two universities in the Philippines were chosen to provide contrasting communities within the overall Catholic ethos of the country. UAP could be regarded as an intellectual centre closest to the teachings of the magisterium of the Church. Opus Dei is rightly regarded as a bastion of traditional Catholic teaching because it has scrupulously upheld the full and undiluted doctrine of the church. LIT, in contrast, is a comparatively small regional university, chosen because it had no metropolitan glitter about it, was state-run and attracted a technically oriented clientele from financially and socially modest homes, in one of the poorest provinces of the country. The strong Catholic orientation of the Philippines was very apparent, however, in that seminars were normally begun with a prayer and Catholic feast days were regularly observed, even though it was a state university. For the Australian section of the study, respondents were drawn from Adelaide University, which was established as a public institution in the late nineteenth century, the third oldest university in Australia. Situated in the capital city of the state of South Australia, it offers a wide range of degrees across the disciplines of science, agriculture, engineering, the professions, economics, music, humanities and social sciences. The student body currently numbers close to thirteen and a half thousand. Like most government-funded educational institutions in Australia, Adelaide University is strongly secular in ethos and has traditionally regarded religion and theology as sectarian pursuits, inappropriate for university students, while its philosophy department has been openly atheistic (Duncan and Leonard, 1974). The students participating in the study came from the Graduate School of Education. Poland and the Philippines, the two predominantly Catholic countries investigated in this study, both inherited a strong Catholic tradition anchored in the post-Tridentum spirit. The respondents from the four Polish and Filipino universities who claimed to be Catholic (over 80%) would formally be expected to uphold the religious and moral values prescribed by their church and know that any deviation would be regarded as a sin. Evidence on which values were being rejected or regarded more relativistically and how frequently constitutes valuable information on changes taking place in moral values in countries which have long been regarded as strongholds of Catholicism. METHOD Student participants from the five universities were asked to complete a questionnaire on their religious and moral beliefs. For students in the Philippines and Australia the questionnaire was in English, but a Polish version was used for the respondents from Poland. Some questions were designed to gather concrete data concerning the respondents’ background: gender, age, language use, level of parental education and religious affiliation. There was also a series of questions to gather cultural data i.e. these were concerned with the students’ beliefs and moral perceptions and other attitudes in relation to the moral/religious convictions among them. Responses to Specific Moral Issues When presented with moral issues which epitomized contemporary moral dilemmas, participants were asked to indicate whether they agreed that action concerned was wrong: whether its moral status depended on the situation; or whether they considered the action not wrong. The range of responses available was: †¢ †¢ †¢ †¢ Considered Wrong Situation dependent Not wrong No opinion The questions and responses were thus deliberately framed in terms of the maintenance of traditional moral values. Data were initially summarized in frequency distributions for each university. Of the twelve situations presented to the respondents, one example from each category of issues will be discussed. viz. Abortion classified as a ‘Life and Death issue’: Abortion: A Life and Death Issue This issue proved important in the analysis because of the polarisation of data. There was a clear distinction between the percentage of responses which considered abortion to be wrong from the three Catholic oriented universities, including LIT, and the two more secular ones. Traditional moral values on abortion were strongly maintained on this issue especially at the three Catholic oriented universities: UAP (93%), KUL( 80%) and LIT (74%) while in Warsaw (49%) only half gave evidence of supporting these values. Even lower, the Adelaide figure of 25% who considered abortion to be wrong, could be seen to reflect a society where abortion is legally available, virtually ‘on demand’. In the case of responses rejecting traditional values, Adelaide respondents (44%) stood out as having the highest percentage of rejectors of traditional values. Warsaw (12%) is aligned with LIT on 15% in this response an indication of much lower rejection among students who lived in predominantly Catholic societies, than the secular society of Adelaide which largely accepted abortion. Abortion was an issue of debate, depending on the situation, for students from Adelaide (30%) and Warsaw (34%) rather than for the three Catholic-oriented universities LIT (4%), UAP (6%) and KUL (14%). These students were upholding the traditional Catholic teachings. The situational response indicated that some students considered an issue was neither right nor wrong in itself. If they had doubts about it, they could choose this option to record individual responses . Extra-Marital Affairs: A Sex and Marriage Issue There was a marked convergence of responses in relation to this issue. The majority of students from all five universities agreed in maintaining traditional opposition to such actions: UAP were unanimous on 99%. Warsaw(70%) and Adelaide (69%) showed a similar stance in opposing this issue. In this regard, Warsaw and Adelaide respondents almost matched the frequency levels from LIT at 73% and KUL at 85%. The ‘ranking’ of the university responses is similar to the previous issue, abortion, but there is general consensus. The responses on the upholding of traditional moral values had their mirror image in the data showing rejection of such values. There was strong evidence of less acceptance for ‘extramarital affairs’ at Warsaw (1%) and Adelaide (5%) where responses to this option were at a very low level, comparable to UAP(1%) and KUL (1%). The respondents at LIT (14%) showed some approval of the issue but the number was relatively small. The third response option, reflecting a more situational approach, was valuable in highlighting issues where there was a high degree of ambiguity or uncertainty. Low scores, in contrast, suggested that the respondents in the group concerned had made up their minds to be either upholders or rejectors of traditional morality. The relativistic view was comparatively high and shared by as many as 26% from Warsaw and 23% from Adelaide indicating the doubts some students expressed depending on the situation. STEALING: A Human Relations Issue The issue of ‘stealing’ was also striking in the way a large degree of consensus was displayed among students from all universities but the pattern of response differed markedly from those shown for the other two issues. ‘Stealing’ elicited the highest response of moral rectitude with over 70% of students in all universities and over 80% in three of them considering stealing as ‘wrong’. ‘Stealing’ was also the issue which elicited the highest level of support for any traditional value among Warsaw students (87%). With a corresponding figure of 82% at KUL, stealing seems to evoke a particularly strong sense of ‘wrong’ among Polish students. It is interesting to note that UAP students, who were the highest upholders of moral values on virtually all other issues, were below Warsaw at 81% in the case of ‘stealing’. Adelaide students with their dual Protestant and secularist orientations, also demonstrated greater acknowledgment of ‘stealing’ as ‘wrong, than for any other issue (74%). At Adelaide 41% of respondents indicated that they belonged to one of the Protestant denominations whilst 30% claimed that they had no religion a response which did not occur at all in any of the other groups of participants. The remarkable unanimity of responses for this issue from students at all universities was also seen in the complementary rejection of traditional values, in that only very few claimed outright that ‘stealing’ was not wrong. Only LIT showed a relatively high proportion of those rejecting traditional values, amounting to 14%. In contrast, while on most moral issues Warsaw and Adelaide displayed a high degree of permissiveness, Adelaide showed no more than 4% of respondents, and Warsaw had no-one who condoned stealing. The figures for KUL and UAP were minimal 3 and 2%. Overall stealing was not acceptable as an issue. The minimal number of students at Warsaw and KUL, UAP and Adelaide who openly condoned stealing has to be considered alongside the proportion who expressed relativistic attitudes by indication that their judgement of whether stealing was ‘wrong’ or ‘not wrong’ would depend on the circumstances. Respondents from Adelaide (21%) and UAP (17%) expressed some doubt in relation to stealing which was somewhat higher than Warsaw (12%) and KUL (16%). The figure for LIT was as low as 6% which reflects the pattern for all universities as seeing stealing as ‘wrong’. These findings suggest that moral issues in social relationships are not necessarily seen to be tied directly to Christian beliefs, despite their specific prohibition in the Ten Commandments. Findings raise questions such as : Is stealing related to established ‘legal’ rather than ‘moral’ codes? For some Protestants, what constitutes sin and restitution for sin becomes very much more a matter for the individual conscience and there is a greater tendency to adopt relativistic attitudes where what constitutes right and wrong depends on personal judgement of the situation. CONCLUSIONS The various responses to these three issues provide valuable information on the relative ‘holding power’ of Christian (mainly Catholic) beliefs in Poland and the Philippines when compared with mainly Protestant (or religiously indifferent) Australia. The responses also throw light on differences among the various moral values examined, in the extent of their support or rejection. In the three predominantly Catholic universities (UAP, LIT and KUL), traditional Christian values continued to be upheld for ‘abortion’ in the life and death issue. In the two universities where there has been a tradition of secularist values, there is a much greater rejection of traditional moral values, together with a substantial number of those with a relativistic orientation expressing an essentially ambiguous stance. One issue on which Warsaw and Adelaide join forces with the Catholic oriented University is on the issue of ‘extra-marital affairs’, a ‘Sex and Marriage Issue’, with about two third of responses upholding a traditional negative view of such practices. This particular value appears to hold no relationship to Christian religious belief or non-belief, assuming a virtually universalistic dimension. The same situation apprears to hold for the ‘social relationship’ issue stealing. Responses from students in all five universities favour the upholding of traditional moral values for this issue which is considered more frequently ‘wrong’ by Warsaw students than by respondents from all other universities. There is a minimal rejection of the traditional norms that condemn ‘stealing’. It is the rejection of certain moral propositions when the respondents openly admit that certain actions which are contrary to traditional morality are no longer ‘wrong’ which put them in conflict with the religious authority to which they officially subscribe. What is clear is that some of the traditional values are changing within the orbit of particular Christian denominations. The results suggest that believers display a spirit of selectivity among moral values showing traditional disapproval for certain actions, while revealing a proclivity for greater permissiveness in relation to others. The issue of abortion shows that in the Catholic oriented universities, there is little evidence of collapse of traditional values and that globalization trends have not seriously undermined other traditional values. The other two moral issues discussed, extra-marital affairs and stealing, where there is a greater convergence of responses, can be viewed as highlighting more univer salistic values which appear to go beyond the confines of any particular religious belief. REFERENCES Andres, T. D. (1980) Understanding Values. Quezon City: New Day Publishers. Blumer, H. (1939) Critiques of Research in the Social Sciences I: Appraisal of Thomas and Znaniecki’s ‘The Polish Peasant in Europe and America’. New York: Social Science Research Council. Duncan, W.G.K. and Leonard, R.A. (1974) The University of Adelaide. Adelaide: Rigby. Ossowska, M. (1985) Normy Moralne: Proba Systematyzacji. P.W.N. Warszawa. Smolicz, J.J. (1997) In Search of a Multicultural Nation, in R. J. Watts and J.J.Smolicz (eds), Cultural Democracy and Ethnic Pluralism: Multicultural and Multilingual Policies in Education. Frankfurt am Main: Peter Lang. Smolicz, J.J. (1999) On Education and Culture. (M.J. Secombe and J. Zajda, eds) Melbourne: James Nicholas Publishers. Smolicz, J.J., Secombe, M.J. and Hudson, D.M., (2001) Family Collectivism and Minority Languages as Core Values of Culture among Ethnic Groups in Australia, Journal of Multilingual and Multicultural Development, vo l. 22:2. Znaniecki, F. (1963) Cultural Sciences: Their Origin and Development. Urbana: University of Illinois Press. Znaniecki, F. (1969) On Humanistic Sociology: Selected Papers (Bierstedt, R. ed.). Chicago: University of Chicago Press. Znaniecki, F. (1998) Education and Social Change. (Halas, E. ed) Frankfurt am Main: Peter Lang.

Friday, September 20, 2019

Analysis of Drug Delivery Systems

Analysis of Drug Delivery Systems INTRODUTION SECTION 1.1: ORAL DRUG DELIVERY SYSTEM A drug delivery system is defined as a formulation or a device that can be introduce the therapeutic or pharmaceutical substance in to the body and improves the efficacy and safety of substance by controlling the time, rate and place of drug release in the body. Drug delivery system is an interface between the patient and the drug. It may be a formulation of drug to administer it for a therapeutic or medical reason or a device used drug delivery. Oral drug delivery system is most desirable, preferable and suitable route for the administration of therapeutic and pharmaceutical agents for administration. Historically the oral route of drug administration has been the one used most for both conventional as well as the novel drug delivery. The reasons for this preference are obvious because of ease of administration. Oral drug delivery is the most desirable, suitable and preferred method of administering therapeutic agents for their systemic effects. The oral medication is mostly conside red as the first investigation in the development and discovery of new drug molecules and pharmaceutical preparations, mainly because of acceptance by the patients, convenience, and cost effective manufacturing process. For many drug substances conventional immediate release formulations provide clinically and therapeutically effective therapy while maintaining the required level of pharmacodynamic and pharmacokinetic profiles with acceptable level of safety to the patient. Multiple unit dosage forms such as microspheres or micro beads have gained in popularity as oral drug delivery systems because of high uniformity of the drug distribution in the gastrointestinal tract, better drug absorption, minimized local irritation and elimination of unwanted intestinal retention of polymers and other excipients, when compared to non-disintegrating single unit dosage form.2 SECTION 1.2: CONTROLLED DRUG DELIVERY SYSTEM A wide variety of newer oral drug delivery systems like sustained/controlled release dosage forms are designed and evaluated in order to overcome the limitations of conventional therapy. These products are able to maintain steady drug plasma levels for extended periods of time as a result the variations of the drug levels in the blood are prevented and minimized drug related side effects.3 The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the time period of therapeutic activity and targeting the drug delivery to a tissue. Drug release from these systems should be at a desired rate, predictable and reproducible. Among the various approaches for controlled systems, microencapsulation process and microcapsules have gained good acceptance as a process to achieve controlled release and drug targeting.4 The goal in designing sustained or controlled delivery system is to reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site action, reducing the dose required, or providing uniform drug delivery.5 Of growing interest generally in the world of oral drug delivery is colon-targeted delivery for treatment of both local and systemic conditions. It is recognised that this region of the Gastrointestinal tract offers advantages over the stomach and small intestine, e.g. milder pH, lower enzymatic activity, lower bile salt concentrations, longer residence time and slower turnover of the mucus layer. For biopharmaceutical delivery, it also appears to offer the benefit of allowing greater functioning of absorption enhancers, thus allowing reasonable bioavailability of drugs such as peptides which would normally be poorly absorbed from the GI tract.6 Controlled release systems are used in the improvement of the effectiveness of drug therapy. These systems modify several parameters of the drug: the release profile and capacity to cross biological carriers (depending on the size of the particle), biodistribution, clearance, and stability (metabolism), among others. In other words, the pharmacokinetics and the pharmacodynamics of the drug are modified by these formulations. Controlled release offers numerous advantages over conventional dosage forms. This approach increases therapeutic activity and decreases side effects, thus reducing the number of drug dosages required during treatment. Controlled release methods offer an appropriate tool for site-specific and time-controlled drug delivery. There are two main situations in which the distribution and time-controlled delivery of a drug can be beneficial- When the natural distribution of the drug causes major side effects due to its interaction with other tissues. When the natural drug distribution does not allow it to reach its molecular site of action due to degradation. Many different kinds of drugs can benefit from distribution or time-controlled delivery, such as anti-inflammatory agents, antibiotics, chemotherapeutic drugs, immunosuppressants, anesthetics and vaccines.7 1.2.1: Advantages of oral controlled release formulations Oral controlled drug delivery has been widely preferred in research because of its large number of benefits over conventional dosage forms, some of which are as follows: The frequency of dosing is less due to drug being released for a longer duration of time than conventional dosage form. This is highly valuable for the patients with chronic disease and illnesses which required to maintaining the plasma concentrations of a drug within the range of therapeutic effects to avoid breakthrough symptoms. The reduction or avoidance of side effects due to high plasma drug concentrations or ‘dose dumping’. Improvement of the patient compliance because of reduced dosing. Better control on the concentration of therapeutic drug in body. Cost effective manufacturing as the amount of dose required per patient would be reduced as compared to its conventional dosage form.8 SECTION 1.3: COATING OF FORMULATION Coating is defined as a process by which dosage form is covered with an essentially dry, outer layer of coating material by applying it on the surface of a formulation or dosage form for specific benefits that broadly ranges from improving product identification to modifying the release of the drug from the formulation. After making a good formulation, one must often coat it for many benefits. There are five reasons for putting such a coating on a pharmaceutical formulation: Protection of active pharmaceutical ingredients, from the acidic environment of the stomach (e.g. enzymes and certain antibiotics). To prevent gastric distress or nausea from a drug due to irritation (e.g. sodium salicylate ). For the delivery of drugs that are optimally absorbed in the small intestine to their primary absorption site in their most concentrated form. To provide a delayed/sustained release of drug substance for repeat action. Required for minimizing first pass metabolism of drugs.19 1.3.1: Coating material The coating material should be capable of forming a film that is cohesive with the materials required for coating, should be chemically compatible with the material and must be non reactive with the core material and provide the desired coating properties such as strength, impermeability, optical properties stability and flexibility. When coating is done by microencapsulation techniques the size of thickness of coating is in microscopic units. A number of different substances both non-biodegradable and biodegradable have been investigated for the formulation of microcapsules. These materials include the polymers of synthetic natural and origin and also modified natural substances. Some of the polymers used in the preparation of the microcapsules are classified and listed. 1.3.2: Ideal properties of an enteric coating material Resistance from the gastric fluids Permeable/Susceptible to the intestinal fluid Should be compatibility with the most components of coating solution and the substrates of the drug Formation of uniform and continuous film Cheap, nontoxic and easy to apply Provide ability in readily printed19 1.3.3: EUDRAGIT S100 Eudragit S100 is anionic copolymers based on methacrylic acid and methyl methacrylate. The IUPAC name of edragit S100 is Poly(methacrylic acid-co-methyl methacrylate). Eudragit S100 contains 30% of methacrylic units and dissolves at pH values higher than 7.0. Eudragit S100 is suitable coating agent for controlled and colon targeted drug delivery system.10 Eudragit S100 is an effective and stable enteric coating agent with fast dissolution in upper bowl. It is generally accepted that pH7 is not normally reached until at least the distal small bowel/ileocaecal region; thus drug release from formulations coated with Eudragit S100 is likely to commence at the junction between the small intestine and colon, continuing into the colon.6 SECTION 1.4: NON-STEROIDAL ANTIINFLAMATORY DRUGS Non-steroidal anti-inflammatory drugs (NSAIDs) are considered to be the first-line drugs in the symptomatic treatment of rheumatoid arthritis, ankylosing spondilytis and osteoarthritis. Aceclofenac is one of the emerging NSAID molecules for the treatment of arthritis. Aceclofenac is a new derivative of diclofenac and has less gastrointestinal complications. All drugs grouped in this class have analgesic, antipyretic antiinflammatory action in different measures. They do not depress CNS, do not produce the physical dependence, are weaker analgesics and have no abuse liability. They are more commonly employed and many are over-the-counter drugs.21 1.4.1: ACECLOFENAC Aceclofenac is a non-steroidal anti-inflammatory drug, widely used in the management of osteoarthritis, ankylosing, rheumatoid arthritis and spondylitis. Usual therapeutic dose is 100 mg twice daily and half life is 3-4 hrs; thus it is necessary to be administered frequently in order to maintain the desired concentration. 1.4.2: MECHANISM OF ACTION Aceclofenac drug acts as non selective inhibitor of cyclooxygenase enzyme(COX). It inhibits both cyclooxygenase-1(COX-1) and cyclooxygense-2 (COX-2) isoenzymes. COX catalyses the formation of prostaglandin and thromboxane from archidonic acid. Prostaglandins act like messenger molecules in the process of pain and inflammation. Aceclofenac also have antipyretic activity and be used in treatment of pyrexiya. The reason of fever is the elevation in the levels of PGE2. Aceclofenac inhibits the biosynthesis of PGE2 within the hypothalamus to reduce the fever. Archidonic acid is precursor substrate for COX which helps to lead the production of prostaglandins F, D and E.22 SECTION 1.5: MICROENCAPSULATION Microencapsulation is a rapidly expanding technology for the preparation of formulatios in which drug is present as core material covered by polymer. As a process, it is a means applying relatively a thin coating to small solid particles or liquids droplets and dispersions. Microencapsulation is arbitrarily differentiated from macro-coating techniques in that the farmer involves the coating of particles is in the range between several tenths of a micron to 5000 microns in size.23 Microencapsulation is process by which thin coating can be applied reproducibly to small solids particles or liquid droplets or dispersions or even gases are encapsulated into micro sonic particles. Particle size range dimensionally from 1 Â µm to 1000 Â µm.9 Particulate drug delivery system are gaining more prominence in recent years because they uniformly distribute in the GIT there by improve the bioavailability of the drugs and also reduces the local irritation. Due to attractive properties and wider applications of microparticles, their application in controlled release formulation is appropriate. Microencapsulation is a rapidly expanding technology. Microencapsulation helps in converting the liquids into the solids, altering colloidal and surface properties of formulation, in providing environmental and external protection and in controlling the release behaviour or availability of coated materials. 1.5.1: Applications of microencapsulation In the development and the design of controlled and sustained release dosage form. Alteration in site of absorption. To mask the taste of bitter drugs. To provide the protection to the core material from atmospheric effects. To minimize gastric and other GIT irritation. In the preparation of free flowing powder formulations from drugs in liquid forms. Stabilization of drugs which are sensitive to moisture, light or oxygen. In the elimination of incompatibilities among drugs. Prevention of volatile drugs from vaporization. Reduction of toxicity. To reduce hygroscopicity. Alteration in site of absorption. 1.5.2: MICROENCAPSULATION BY IONOTROPIC GELATION METHOD Alginates have ability to form gels by reaction with calcium salts. Alginic acid is composed of D-mannuronic acid and L-gluronic acid residues at varying proportions of GG-, MM- and MG- blocks. When suspension of alginate is added drop by drop to the solution of calcium salt, crosslinking takes place between the carboxylate residue of GG- blocks and Ca+2 ions via egg-box model to give a tight gel network structure. This method is called ionotropic gelation method because in this process the anion of alginate and cation of calcium salt (mostly Ca+2ion) crosslinked to form a gel. These gels resemble a solid retaining their shape, resisting stress and consist of almost 100% water. It has been suggested that the cross-links are caused by simple ionic bridging of two carboxyl groups on adjacent polymer chain via calcium ions or by chelating of single calcium ions by hydroxyl and carboxyl groups on each a pair of polymer chains.24 In this method strong spherical beads with a narrow range particle size distribution and lower friability could be prepared. Beads formed by this method have high yield and drug content. The flow properties of micronized of needle like drug crystals can be improved by the help of agglomeration technique as compared to the non-agglomerated drug crystals. The ionic character of the polymers results from pH dependent disintegration of the beads. SECTION 1.6: GEL BEADS Gel beads are defined as spherical structure in which drug is present in the core of beads. Different types of gel beads can be prepared by using various techniques. Gel beads help in the slow dissolution of drug hence slowdown the release of drug, thus results in improvement of bioavailability of drug. 1.6.1: APPLICATIONS GEL BEADS Stomach specific drug delivery using floating alginate gel beads A multiple unit type oral floating dosage form of many drug have been developed in recent years. Drugs like riboflavin, ranitidine, diclofenac sodium were formulated to prolong the gastric residence time and increase bioavailability. Colon targeting Beads of various drugs have been formulated and further coated with enteric polymers for colon targeting. Protein drug delivery In recent years many formulations have been prepared for protein drug molecules for site specific release of protein in the intestine. Microbeads as inoculants and carriers for plant growth-promoting bacteria Beads of various bacteria are developed in recent years to promote the growth of plants. The release of bacteria from the microbeads depends on its type (wet or dry) and the time of incubation (the longer the incubation time, the smaller the extent of bacteria released with time). Enzyme immobilization Enzymes are immobilized by formation ofdehydrated gel beads for use in non-aqueous enzymatic reactions by having an average particle size of 5 to 150 microns.

Thursday, September 19, 2019

guide :: essays research papers fc

A Student Guide to Writing a History Paper The first thing that you may ask is why write papers at all? Writing is an invaluable part of the educational process, because writing forces you to take your knowledge of a subject, and organize it all into a coherent and concise presentation. Furthermore, it forces you to dig deeper and uncover interesting information about a person or event that might otherwise be mentioned during instructional time. There is another practical reason why you should write well. After you graduate, many of those with whom you will have contact in your professional life will judge you and your work based upon your writing. Whatever career path you choose, you will have to write letters, reports, speeches, proposals, etc., that others will read before they ever hear the sound of your voice. These individuals will develop their first and often lasting impression of you based on your writing skills. Writing is a skill and like any skill is fine-tuned through practice. When you write history papers, use this as a guide and it will improve your final product. ________________________________________________________________________ Thesis Statement Before you start writing your paper, develop a carefully constructed thesis. Every paper must have a thesis. Your thesis should be stated clearly in the introduction of the paper so the reader is not left to wonder just what argument you are making. If you cannot say what you want in one or two sentences, then your thesis is probably to broad. The thesis statement does not have to be in the first sentence of your paper (although it can be) but it should appear somewhere on the first page. In the paragraph that contains your thesis, you should also mention the sort of evidence that you are going to use to offer support for the body of your paper, your argument, and how your topic fits into a broader context of history. Body of the Paper Once you have a clear introduction for your paper, you must elaborate on the argument that you are pursuing. Discuss relevant facts, arguments, and counter-arguments and explain why you think your thesis is correct. Early in the paper you should place your topic in its proper historical context. Go back into the history of your topic only so far as that background is relevant to your argument. Also, do not spend too much time on other people's arguments.

Wednesday, September 18, 2019

The Passing Of Arthur And Excalibur :: essays research papers

John Boorman adapted the †Passing of   Ã‚  Ã‚  Ã‚  Ã‚  Arthur† in the movie â€Å"Excalibur.† Movies are not the only adaptations of Tennyson’s poem but there are several art and music adaptations. Examples of these adaptations include music by Loreena McKennit and paintings by John William Waterhouse, Howard Pyle and Arthur Rackham. In Bela Balazs’s Art Form and Material Balazs states that a good adaptation is a reinterpretation of the original. Boorman uses nature and color to recreate the atmosphere of the original text. These techniques enhance the richness of the movie, provide a more in depth view of Arthur’s life and make the setting more interesting.   Ã‚  Ã‚  Ã‚  Ã‚  Tennyson’s descriptive writing allows the reader to form detailed pictures. The atmosphere Tennyson creates focuses a lot on the beauty of nature. During the scene when Bedivere throws Excalibur in the lake he describes the area with â€Å"zigzag paths, and juts of pointed rock, the shining levels of the lake...the winter moon, long cloud and frost.† He produces an atmosphere of bleakness and despair.   Ã‚  Ã‚  Ã‚  Ã‚  Tennyson concentrates on the image of the winter moon while Bedivere tries to get rid of the Excalibur. This picture makes the reader think that the setting is a winter night. According to Webster’s dictionary, winter symbolizes of coldness, misery or death. Winter is the season when living things die. The moon only comes out during the night. At night people â€Å"rest† from their busy lives and do nothing. Night closely related to winter because both are very dark and bleak times. The lack of light shows the sadness happening to Arthur. As Arthur passes the only light he has comes from the winter moon. The reader gets the feeling that Arthur is heading there. Tennyson chooses dark words and images to create a very desolate and gloomy setting.   Ã‚  Ã‚  Ã‚  Ã‚  Sidney Lumet states in Making Movies â€Å"there are no unimportant decisions in a movie.† Production designers put a lot of effort to recreate the original text. The setting is a very important factor in making a movie. It contributes to much of the style of a movie. Settings reflects many of the directors insights and opinions. There are times where the director goes to great lengths just to form the perfect scene. They leave no detail spared. According to Lumet, a director’s goal is to create a setting so that the audience feels apart of the movie’s world.   Ã‚  Ã‚  Ã‚  Ã‚  When the director needs to find a setting for his/her movie Lumet recommends to â€Å"find places that are closest to what you want to end up with.† If the setting needs to be changed it can change the atmosphere and become expensive too. Art direction

Tuesday, September 17, 2019

Non Hormonal Methods Of Contraception Health And Social Care Essay

The planetary human immunodeficiency virus ( HIV ) pandemic is progressively going a load of the female population. HIV is preponderantly acquired through heterosexual transmittal and in many parts of the universe, HIV prevalence and incidence rates are higher among adult females than work forces ( Daly et al 1994 ) . At the terminal of 2007, an estimated 15.4 million adult females were infected with HIV, most of them being of fertile age ( Heikinheimo and Lahteenmaki 2008 ) . Importantly, immature adult females aged 15-24 have a 4- to 7-fold increased hazard of going infected with HIV, when compared with immature work forces of the same age ( Simon et al. , 2006 ) . The demographics and paths of infection vary harmonizing to the stage of the HIV epidemic ( Beyrer, 2007 ) . Womans with HIV infection may wish to be after gestation to restrict their household or avoid gestation. The pick of contraceptive method in people populating with HIV is constrained by the demand to forestall bot h sexual transmittal of HIV and unwanted gestations. Correct usage of most user dependant methods requires a basic cognition of reproduction and literacy accomplishments to follow written instructions. Double map preventives that at the same time prevent HIV transmittal every bit good as unwanted gestations might be the most appropriate prophylactic method for adult females populating with HIV and AIDS ( Kakaire et al, 2010 ) .Main BodyThe human immunodeficiency virus ( HIV ) is a retrovirus belonging to the household of lentiviruses. Retroviruss can utilize their RNA and host Deoxyribonucleic acid to do viral DNA and are known for their long incubation periods. Like other retroviruses, HIV infects the organic structure, has a long incubation period or clinical latency, and finally causes the marks and symptoms of disease. HIV causes terrible harm to the immune system and finally destroys it by utilizing the Deoxyribonucleic acid of CD4+ cells to retroflex itself. In that procedure, the virus finally destroys the CD4+ cells ( Calles et al. 2010 ) . There are two types of human immunodeficiency virus ( HIV-1 and HIV-2 ) , which each evolved from a different simian immunodeficiency virus ( SIV ) . Both viruses emerged in the late twentieth century. In contrast to the SIV ‘s, which appear non to harm their natural archpriest hosts. HIV infection amendss the immune system, go forthing the organic structure susceptible to infection with a broad scope of bacteriums, viruses, Fungis, and Protozoa ( Calles et al. 2010 ) . Surveies have shown dramatic similarities but besides of import differences between HIV-1 and HIV-2. They have the same manners of transmittal and are associated with the same timeserving infections, but HIV-2appears to come on at a slower rate ( CDC ) . HIV-1 is much more prevailing than HIV-2. It is HIV-1 that is mostly responsible for the AIDS pandemic, while HIV-2 is chiefly restricted to West Africa. Now, in each twelvemonth of the early twenty-first century there are about 5 million new HIV infections, and about 3 million deceases from AIDS, which has become the 4th biggest cause of mortality in the universe ( Carter and Saunders 2007 ) . HIV-1 infection is characterized by an insidious impairment of the cellular immune system ( Vergis and Mellors 2000 ) . Both the measure and proportion of plasma CD4+ T-cells lessening steadily over a period of old ages to decennaries, and this progressive loss of CD4+ T-cells is associated with the development of AIDS in septic persons. The grade of immunodeficiency associated with HIV-1 infection, as defined by the oncoming of timeserving diseases, correlatives closely with plasma CD4+ T-cell counts ( Calles et al. 2010 ) . HIV ‘s Life Cycle Host cells infected with HIV have a sawed-off life span as a consequence of the virus ‘s utilizing them as â€Å" mills † to bring forth multiple transcripts of new HIV. Thus, HIV continuously uses new host cells to retroflex itself. Equally many as 10 million to 10 billion virions ( single viruses ) are produced day-to-day. In the first 24 H after exposure, HIV onslaughts or is captured by dendritic cells in the mucose membranes and tegument. Within 5 yearss after exposure, these septic cells make their manner to the lymph nodes and finally to the peripheral blood, where viral reproduction becomes rapid. CD4+ lymphocytes that are recruited to react to viral antigen migrate to the lymph nodes. These become activated and so proliferate via complex interaction of cytokines released in the microenvironment of the lymph nodes. This sequence of events makes the CD4+ cells more susceptible to HIV infection, and it explains the generalised lymphadenopath y feature of the acute retroviral syndrome seen in grownups and striplings. In contrast, HIV-infected monocytes allow viral reproduction but resist violent death. Therefore, monocytes act as reservoirs of HIV and as effecters of tissue harm in variety meats such as the encephalon ( Calles et al. 2010 ) . The HIV life rhythm includes six stages harmonizing to Calles et Al. ( 2010 ) binding and entry, rearward written text, integrating, reproduction, budding, and ripening ( Figure 1. Appendix 2. ) . Binding and Entry, the envelope proteins gp120 and gp41 bind to CD4+ cell receptors and co-receptors on the exterior of CD4+ cells and macrophages. The chemokine receptors CCR5 and CXCR4 facilitate viral entry. T-cell tropic viruses require CXCR4 to adhere, and macrotropic strains of the virus require CCR5. R5 is the most common virus transmitted during acute infection, and subsequently during infection X4 is the virus that is most common. The presence of a homozygous inactive mutant of the CCR5 allelomorph has caused opposition to infection by the R5 virus. The connection of the proteins and the receptors and co-receptors fuses the HIV membrane with the CD4+ cell membrane, and the virus enters the CD4+ cell and macrophage. The HIV membrane and the envelope proteins remain outside of the CD 4+ cell, whereas the nucleus of the virus enters the CD4+ cell. CD4+ cell enzymes interact with the viral nucleus and excite the release of viral RNA and the viral enzymes rearward RNA polymerase, integrase, and peptidase. The HIV RNA must be converted to DNA before it can be incorporated into the Deoxyribonucleic acid of the CD4+ cell. This incorporation must happen for the virus to multiply. The transition of HIV RNA to DNA is known as contrary written text and is mediated by the HIV enzyme contrary RNA polymerase. The consequence is the production of a individual strand of Deoxyribonucleic acid from the viral RNA. The individual strand of this new DNA so undergoes reproduction into dual isolated HIV DNA. Once rearward written text has occurred, the viral DNA can come in the karyon of the CD4+ cell. The viral enzyme integrase so inserts the viral DNA into the CD4+ cell ‘s Deoxyribonucleic acid. This procedure is known as integrating. The CD4+ cell has now been changed into a mill used to bring forth more HIV. The new DNA, which has been formed by the integrating of the viral DNA into the CD4+ cell, causes the production of courier Deoxyribonucleic acid that initiates the synthesis of HIV protei ns ( Calles et al. 2010 ) . The HIV proteins and viral RNA, all the constituents needed to do a new virus, gather at the CD4+ cell membrane to organize new viruses. These new viruses push through the different parts of the cell wall by budding. Many viruses can force through the wall of one CD4+ cell. These new viruses leave the CD4+ cell and contain all the constituents necessary to infect other CD4+ cells. The new virus has all the constituents necessary to infect other CD4+ cells but can non make so until it has matured. During this procedure, the HIV peptidase enzyme cuts the long HIV proteins of the virus into smaller functional units that so reassemble to organize a mature virus. The virus undergone the procedure of ripening and is now ready to infect other cells ( Calles et al. 2010 ) . Safe and effectual methods of contraceptive method represent a critical constituent of preventative wellness attention cut downing maternal and infant mortality ; particularly in adult females populating in resource-limited scenes ( Zdenek et al. 2010 ) here is broad fluctuation in contraceptive method prevalence worldwide runing from 8 % of adult females aged 15-49 old ages in western Africa up to 78 % in northern Europe. Female sterilization ( 32 % ) , intrauterine devices ( 22 % ) , and the unwritten preventive pill ( 14 % ) history for more than two tierces of all prophylactic pattern worldwide.4 In less developed states 70 % of contraceptive method users rely on female sterilization and intrauterine devices in portion because they are advocated by health care services as a consequence of cost effectivity in footings of gestation bar and service proviso ( UNPD, 2001 ) . Non-Hormonal Methods of Contraception A high grade of protection against HIV sexual transmittal is provided by consistent correct rubber usage ( Davis and Weller 1999 ) ; inconsistent or incorrect usage is non protective. Most planetary HIV transmittal occurs because rubbers are non used at all during sexual intercourse ( Steiner and Cates 1999 ) .Condom accidents are reported by 1-12 % of users and the method prophylactic failure rate is at least 12 % ( Trussel et al. 1992 ) . Double protection, the coincident usage of an effectual contraceptive method method with consistent rubber usage, has been advocated to cut down the hazard of unplanned gestation, horizontal transmittal of HIV to a non-infected spouse, transmittal of immune virus to an spouse with HIV infection, and the hazard of acquisition of other STIs including high hazard human papillomavirus ( HPV ) types ( UNDP/UNFPA/WHO 2002 ) . Male rubbers are the lone means proven to significantly cut down the hazard of HIV transmittal in heterosexual intercourse ( Cates 2005 ) . Harmonizing to a recent Cochrane reappraisal, consistent usage of male rubbers consequences in 80 % decrease in the hazard of HIV transmittal among HIV-serodiscordant twosomes ( Weller and Davis-Beaty, 2002 ) .The female rubber is a polyurethane sheath with two flexible rings at each terminal ; one ring is inserted into the upper vagina and the other covers the introitus. The female rubber is less likely than male rubbers to leak or interrupt during sex, but invasion of the outer pealing into the vagina is reported in 2 % of copulatory episodes. The cumulative chance of vaginal exposure to seeds with female rubber usage has been estimated as 3 % , compared to 11.6 % with the male rubber. The prophylactic failure rate is estimated at 5-21 % over 12 months ( Daly et al. 1994 ) . Consistent usage of rubber was associated with holding one spouse, greater income, no illicit drug usage and when rubbers were the lone preventive method used ( Wilson et al. 1999 ) .Women who besides use, effectual or long term methods of contraceptive method are less likely to describe consistent rubber usage ( Magalhaes et al. 2002 ) . Condom usage is besides related to whether the adult female has informed her spouse of her position ( DesgreA?es-du-LouE†  et al. 2002 ) less consistent usage is reported by concordant twosomes ( Clark et al. 1997 ) , even within discordant partnerships consistent rubber usage is reported by merely about 50 % twosomes ( Allen et al. 2003 ) .Obstacles to greater usage of male rubbers include deficiency of handiness, fright of being perceived as holding multiple spouses and being unfaithful to a regular spouse, resistance on spiritual evidences, and male laterality in determination devising ( UNDP/UNFPA/WHO, 2002 ) . Women populating with HIV inf ection may experience unable to unwrap their HIV position and negotiate rubber usage with new sexual spouses for fright of forsaking, domestic force, loss of economic support, and societal isolation. The issues around female rubber usage are besides negociating barrier method usage, ( Kalichman et al.2000 ) method acceptableness by users, and higher cost compared with the male rubber. The WHO audience on reuse suggested that female rubbers still run into fabrication quality appraisal specifications after seven rhythms of bleach disinfections, rinsing, drying, and relubrication. This protocol has non been evaluated for safety and efficaciousness in human usage and the WHO does non urge or advance reuse of female rubbers and is presently patronizing research to measure reuse protocols under local conditions ( WHO, 2002 ) . Furthermore, stop and vimules cover the neck and parts of the vaginal wall, while caps cover merely the neck. Their usage in discordant twosomes is non recommended, as a comparatively big country of vaginal mucous membrane remains exposed, micro injury during interpolation, and the accompaniment usage of nonoxynol-9 spermatocide may do epithelial break and increase viral transmittal hazard to the male spouse ( Carlin and Boag 1995 ) . Nonoxynol-9 ( N-9 ) spermatocide provides no protection against sexually familial infections including HIV ( Wilkinson et al. 2002 ) and frequent usage increases the hazard of HIV acquisition ( Van Damme et Al. 2002 ) . WHO Contraceptive Research and Development ( CONRAD ) proficient audience concluded that N-9 should non be used or promoted for the bar of HIV in adult females at high hazard of infection ( WHO 2001 ) . There are no published surveies on the female-male transmittal hazard with N-9 usage by adult females with HIV infection. It seems advis able for adult females with HIV infection with discordant sexual spouse to avoid N-9 spermicidal entirely or with other prophylactic methods to cut down the possible hazard of HIV sexual transmittal. There is no grounds that rubbers lubricated with N-9 are more effectual in forestalling gestation than rubbers lubricated with silicone. However, where pick is limited it is better to utilize any rubber than no rubber at all. In the hereafter, effectual and acceptable micro biocides may hold a function, supplying HIV positive adult females unable to negociate consistent rubber usage with a discordant spouse with an extra method to cut down sexual transmittal. HORMONAL METHODS OF CONTRACEPTION The combined unwritten preventive ( COC ) pill is an effectual user dependent contraceptive method with the non-contraceptive benefits of rhythm control, decrease in hypermenorrhea and dysmenorrhoea. Absorption can be affected by drawn-out intercurrent diarrhea and emesis. The COC is metabolised by the liver and its usage is contraindicated in adult females with unnatural liver map, which may be caused by intoxicant maltreatment, ague or chronic viral hepatitis, and inauspicious events on antiretroviral combinations. These factors are peculiarly relevant when doing contraceptive method picks for HIV positive adult females who are current or old shooting drug users with chronic active hepatitis C infection. Current drug users frequently have a helter-skelter life style that precludes effectual usage of user dependent contraceptive method methods ( Mitchell and Stephens, 2004 ) . Progestogen ( POP ) merely pills methods may be used by adult females with contraindications to estrogen usage. The POP is an effectual preventive method with right and consistent usage ; ovulation is non inhibited in all users, and inconsistent usage can ensue in gestation. A new progestin merely pill, Cerazette, which contains 75 milligram desogestrel, has late been introduced. In surveies Cerazette inhibited ovulation in97 % of rhythms at 7 and 12 months after induction ; this would propose enhanced efficaciousness in comparing with conventional POPs, though as yet unconfirmed by comparative tests ( Mitchelle and Stephens, 2004 ) . Under the long playing progestin merely contraceptive method, depot Provera ethanoate ( DMPA ) 150 milligram is given by deep intramuscular injection at 12 hebdomadal intervals and norethisterone oenanthate ( Noristerat ) 200 mg every8 hebdomads. These methods have the advantage of non being intercourse related but require regular entree to wellness attention for repetition injections. Likewise, implants need to be inserted by a trained wellness professional. Implanon is effectual for 3 old ages, and Jadelle for 5 old ages ( non licensed in the United Kingdom ) ; both are extremely effectual, non-user dependant, and reversible methods of progestin merely contraceptive method. Harmonizing to Mitchell and Stephens ( 2004 ) , factors impacting contraceptive method pick for HIV positive adult females are influence by the state of abode, the handiness of methods, entree to healthcare services, and cost.Religious, cultural, and personal beliefs of the function of adult female in society, acceptableness to spouse, effects on menses. Subsequent is the HIV position of adult female that involves the CD4 count, viral burden and physical well-being. Furthermore HIV serostatus, indefinite spouse concordant and discordant. Then catamenial, sexual, and generative history consist of hypermenorrhea, dysmenorrhoea, past pelvic infection, past ectopic gestation, gestation planning. In add-on the medical history findings like unnatural liver map, past history of venous thromboembolic disease, high blood pressure, lipemia, and current drug maltreatment. Finally the medicines causes such as, enzyme inducers, antibiotics, teratogenic agents. In the survey of ‘contraception among individuals populating HIV with infection go toing an HIV attention and support Centre in Kabale, Uganda ‘ by Kakaire et Al. ( 2010 ) shows that factors independently associated with prophylactic usage were degree of instruction and whether respondent has changed spouses since HIV diagnosing. Contraception usage and conformity is related to the scope of methods available, patient pick, prevailing wellness and spiritual beliefs, perceptual experiences of method effectivity, and side effects ( for illustration, adult females may hold less tolerance for heavy and drawn-out vaginal hemorrhage than amenorrhea ( Playle 2000 ) . Correct usage of most user dependant methods requires a basic cognition of reproduction and literacy accomplishments to follow written instructions. In Gazmararian et Al, ( 1999 ) many states adult females are unable to do independent determinations about their sexual and generative wellness because of political inst ability within society, deficiency of economic independency, and predominating cultural or spiritual attitudes to adult females ‘s rights. The Government ‘s 2001 National Strategy for Sexual Health and HIV outlined policies to cut down degrees of insecure sex, new HIV diagnosings, and undiagnosed HIV by 2007, via puting in bar, bettering outreach services, co-ordinating enterprises and widening information runs. A cardinal mark for a 25 % lessening in freshly acquired HIV infections by 2007 was non met ; new diagnosings have increased significantly. The US Department of Health ( 2009 ) argues that other marks were achieved ; HIV proving increased and clinic waiting times declined. A policy briefing high spots the crisis in presenting just wellness attention for people populating with HIV and AIDS, and the overpowering load it places on adult females and misss. HIV and AIDS have brought an increased demand for community and home-based attention. Due to traditional gender norms and unequal gender dealingss it is the adult females and misss in the communities who are the primary health professionals, whilst perchance being HIV positive, and frequently needing attention themselves.DecisionAt this point in the AIDS epidemic, the bar of the heterosexual transmittal of HIV is of paramount importance ( Daly et al. 1994 ) . Women all over the universe are at hazard for HIV, even within matrimonial relationships. Sing that preventive usage is being promoted worldwide, including in countries where HIV incidences increasing, farther cognition sing the consequence of single preventives on HIV transmittal is imperative. Development and proviso of safe, effectual, low-cost a nd acceptable contraceptive method for adult females at hazard of HIV and those populating with HIV/AIDS is one of the major challenges of generative medical specialty. Currently, consistent usage of male rubbers is the lone proven means to cut down the hazard of HIV transmittal in heterosexual intercourse. All the available reversible prophylactic methods-OCs, prophylactic injections and IUDs-can by and large be used both by adult females at hazard of HIV infection and by HIV-infected adult females. An ideal preventive scheme for adult females at hazard of HIV infection would supply coincident protection against both unintended gestation and HIV acquisition. Word Count: 3,029Appendix 1Mention Lists:Allen, S. , Meinzen-Derr, J.and Kautzman, M. ( 2003 ) . Sexual behavior of HIV discordant twosomes after HIV guidance and testing. AIDS, vol.17, p. 733-740. Beyrer, C. ( 2007 ) . HIV epidemiology update and transmittal factors: hazard and hazard contexts-16th International AIDS Conference Epidemiology Plenary. Clin Infect Dis, vol. 44, p. 981-987. DesgreA?es-du-LouE†  , A. , Msellati, P. and Viho, I. ( 2002 ) . Contraceptive usage, protected sexual intercourse and incidence of gestations among African HIV-infected adult females. DITRAME ANRS 049 Project, Abidjan 1995-2000. Int J STD AIDS, vol. 13, p. 462-468. Calles, N. , Evans, D. and Terlonge, DL. ( 2010 ) . PATHOPHYSIOLOGY OF THE HUMAN IMMUNODEFICIENCY VIRUS. HIV Curriculum for the Health Professional, p. 7-14.http: //bayloraids.org/curriculum/files/2.pdf. Carlin, E.M. and Boag, F.C. ( 1995 ) . Women, contraceptive method and STDs including HIV. International Journal of STD and AIDS, vol. 6, p. 373-386. Carter, J.B. and Saunders, V. A. ( 2007 ) .Virology: rules and applications. England: John Wiley and Sons Ltd. Cates, W. 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Van Damme, L. , Ramjee, G. and Alary, M. ( 2002 ) . Effectiveness of COL-1492, anonoxynol-9 vaginal gel, on HIV-1 transmittal in female sex workers: A randomized controlled test. Lancet, vol. 360, p. 971-977. Vergis, E.N. and Mellors, J.W. ( 2000 ) .A Natural history of HIV-1 infection. Infect Dis Clin North Am, A vol. 14, issue 4, p. 809-825.A Weller, S.C. and Davis-Beaty, K. ( 2002 ) . Condom effectivity in cut downing heterosexual HIV transmittal. Cochrane Database Systematic Reviews, issue 1, p.1-22. Wilkinson, D. , Tholandi, M. and Ramjee, G. ( 2002 ) . Nonoxynol-9 spermatocide for bar of vaginally acquired HIV and other sexually familial infections: systematic reappraisal and meta-analysis of randomised controlled tests including more than 5000 adult females. Lancet Infect Dis, vol, 2, p. 613-617. Wilson, T. , Massad, L.S. and Riester, K.A. ( 1999 ) . Sexual, prophylactic, and drug usage behavior of adult females with HIV and those at high hazard for infection: consequences from the Women ‘s Interagency HIV Study. AIDS, vol. 13, p. 591-598. WHO/CONRAD Technical Consultation on Nonoxynol-9. ( 2001 ) .Geneva, Summary Report. WHO. ( 2002 ) . Information update: considerations sing the reuse of the female rubber, ( www.who.int/reproductive-health/rtis/reuse.en.html ) . Zdenek Hel, Z. , Stringer, E. and Mestecky, J. ( 2010 ) . Sexual activity Steroid Hormones, Hormonal Contraception, and the Immunobiology of Human Immunodeficiency Virus-1 Infection. Endocrine Reviews, vol.31 ( 1 ) , p.79-9.